Amyotrophic Lateral Sclerosis | Cause and Cure(ALS)

Amyotrophic Lateral Sclerosis, cause and cure(ALS)is the topic that  has been bothering scientists and doctors since ages.

Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease, is an unpredictable neurodegenerative disease that affects nerve cells in the brain and spinal cord.

Understanding the unpredictable nature of ALS is essential for developing effective treatments and providing support to patients and their families.

Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis

What do mean by amyotrophic lateral sclerosis (ALS)?

ALS affects a person by degeneration of motor neurons, which are responsible for transmitting signals from the brain to muscles throughout the body.

As motor neurons degenerate, the muscles gradually become weak and useless, leading to muscle spasms, cramps, and eventually paralysis.

The disease often begins with subtle symptoms, making early diagnosis a challenge.

What is ALS caused by?

In most cases the exact cause of ALS remains unknown. However, certain genetic mutations have been linked to familial ALS, accounting for approximately 5–10% of cases.

Most cases of ALS are thought to be sporadic, where no clear genetic cause can be identified.

 Environmental factors and oxidative stress may also play a role in the development of the disease.

Amyotrophic Lateral Sclerosis,Cause and Cure(ALS)-What is ALS and what are its symptoms?

Symptoms and Progression

Symptoms of ALS can vary from person to person, but common symptoms include muscle weakness, difficulty speaking and swallowing, muscle spasms, and impaired motor skills.

As the disease progresses, patients may experience respiratory problems, requiring ventilatory assistance. Diagnosis and Prognosis

Diagnosis of ALS includes a comprehensive neurological exam, electromyography (EMG), and other diagnostic tests to rule out other conditions with similar symptoms.

Unfortunately, there is no cure for ALS, and the prognosis is often poor, with most patients surviving only 2 to 5 years after the onset of symptoms.

What were your first ALS symptoms?

Early symptoms of ALS include: Muscle twitches and spasms: These often affect the legs and arms, but can also involve the tongue.

These can happen whether you are awake or asleep, and they can disturb sleep.

Muscle weakness: You may notice that the muscles of one arm and then the other arm are getting weaker.

Which virus is responsible  for  amyotrophic lateral sclerosis?

The virus suspected  are enteroviruses (EV), a family of positive-stranded RNA viruses including poliovirus, coxsackievirus, echovirus, enterovirus-A71 and enterovirus-D68, in the development of ALS .

Can ALS be cured?

There is no known cure to prevent or reverse ALS. With the passage of time the disease progresses and affects more nerve cells.

What is the top treatment for ALS?

Although there is no known cure for ALS, the drug riluzole is approved for treatment and may slow the progression of the disease.

However, it is expensive and appears to be marginally effective.

Generally, treatment is designed to help control the symptoms. Medications such as baclofen or diazepam can help control spasms.

At what age does ALS start?

ALS is caused between the ages of 40 and 70. The disease  occurs  in people between the ages of twenties and thirties as well.

ALS is 20% more common in males than females.

When was ALS first diagnosed?

The disease was identified by French neurologist Jean-Martin Charcot in 1869 and became more widely known internationally on 2nd June 1941.

It ended the career of one of the famous  baseball player, Lou Gehrig

Current treatments for ALS

Medications and Treatments

Although there is no cure for ALS, several drugs, such as riluzole and edaravone, have been approved to slow the progression of the disease and manage symptoms. 

Assistive device

Assistive devices, such as wheelchairs, communication aids and adaptive devices, can significantly improve the quality of life of ALS patients by increasing their independence and mobility.

Palliative care

Palliative care plays an important role in providing comfort and support to ALS patients and their families.

 It focuses on symptom management and addressing the emotional and psychological challenges associated with the disease.

Ongoing Research and Breakthroughs

  • Stem Cell Therapy

Stem cell therapy holds great potential in ALS research, as it aims to replace damaged motor neurons and restore function. Ongoing clinical trials are exploring the safety and efficacy of this innovative treatment.

  • Gene therapy

Gene therapy seeks to target the specific genetic mutation associated with familial ALS.

By correcting or replacing the faulty gene, researchers hope to stop or slow the progression of the disease.

Biomarkers for preliminary screening

Early detection of ALS is important in order to implement timely interventions.

 Researchers are investigating potential biomarkers that could facilitate early diagnosis, thereby providing patients with better treatment options.

Living With ALS

Coping Strategies

Living with ALS is challenging, but various coping strategies, such as meditation, support groups, and counseling, can help patients and their families cope with the emotional impact of the disease.

Support Systems

It is important for ALS patients to establish a strong support system, which includes family, friends, caregivers, and health care professionals who can provide physical and emotional support.

Enhancing the Quality of Life

Maintaining a positive outlook and focusing on engaging in enjoyable activities can improve the overall quality of life of ALS patients.

Effects of ALS on Patients and Their Families

ALS not only affects patients but also has a profound impact on their families. The challenges of caregiving, emotional distress and financial burden can be overwhelming.

 Raising awareness of these issues is important in order to generate empathy and support.

Advocacy and Support Organizations

Many advocacy and support organizations are dedicated to raising awareness, funding research, and providing resources for ALS patients and their families.

 Their efforts are instrumental in advancing ALS research and supporting those affected by the disease.

Raising Awareness and Fundraising for ALS

Public awareness and fundraising campaigns are essential to support ongoing research and provide care for ALS patients.

Community involvement and initiative can make a significant difference in the fight against ALS.

Which famous people have ALS?

  • Lou Gehrig. ALS is also known as Lou Gehrig’s disease, mainly after Hall of Fame baseball player Lou Gehrig was diagnosed with it in the 1930s.
  • Steven Hawking
  • Paul Cellucci
  • John Stone
  • Mao Zedong
  • Lead Belly
  • Lane Smith 
  • Don Revie

Who is the longest living ALS patient?

Stephen Hawking may have been the longest living ALS survivor.

Who was the youngest ALS patient?

A year ago, eight-year-old Kennedy Arnie was diagnosed with juvenile ALS.

Only seven years old at the time, she became the youngest person diagnosed with the disease in the United States conclusion

Amyotrophic lateral sclerosis remains a complex and unpredictable disease that calls for more research and support.

Although there is no cure, advances in treatment, ongoing research, and increasing awareness provide hope for the future.

 With united efforts, we can strive toward better outcomes for ALS patients and their families.


Amyotrophic lateral sclerosis (ALS) is a complex and unpredictable disease that can have a devastating impact on patients and their families.

However, there is hope for people with ALS because of advances in research and treatment. 

With continued research and support, we can help people with ALS live longer, healthier and more fulfilling lives.

We can also help raise awareness of ALS and help fund research into new treatments. 

Here are some specific things we can do to help people with ALS:

Raise awareness about ALS.

Many people don’t know about ALS, and this can make it difficult for patients and their families to get the help they need.

We can raise awareness about ALS by talking about it with our friends and family, sharing information on social media, and donating to ALS research organizations. 

Fund research into ALS. 

There is still much about ALS that we do not know, and research is necessary to develop new treatments.

We can fund ALS research by donating to ALS research organizations or by participating in clinical trials. 

Support patients and their families.

People with ALS and their families need support to cope with the challenges of the disease.

We can provide help by volunteering our time, donating to ALS support organizations, or simply being there for someone who needs a friend.

By raising awareness, funding research, and supporting patients and their families, we can help people with ALS live longer, healthier, and more fulfilling lives.


Amyotrophic Lateral Sclerosis,Cause and Cure(ALS),What is ALS? 

ALS is known to be a progressive neurodegenerative disease that affects the nerve cells in the brain and the spinal cord.

 It causes muscle weakness and atrophy, eventually leading to paralysis and death.

What causes ALS?

 The exact cause of ALS is unknown, but it is thought to be caused by a combination of genetic and environmental factors.

What are the major symptoms of ALS? 

The symptoms of ALS vary from person to person, but they typically include muscle weakness, muscle twitching, difficulty speaking and swallowing, and fatigue.

How is ALS diagnosed? 

ALS is diagnosed with a combination of neurological exams, electromyography (EMG), and other tests.

Is there a cure for ALS?   

There is no cure for ALS, but there are treatments that can help slow the progression of the disease and manage symptoms.

How long do people with ALS live? 

The average life expectancy for people with ALS is 2-5 years after diagnosis. However, some people with ALS can live for much longer.

What are the risks of ALS? 

The risk of developing ALS increases with age. It is also more common in men than women.

What are the treatments for ALS?

 There are a number of treatments available for ALS, including medications, assistive devices, and palliative care.

What are the research advances in ALS? 

There are a number of research advances being made in ALS, including stem cell therapy, gene therapy, and biomarkers for early detection.

What are the challenges of living with ALS?

 Living with ALS can be challenging, both for the person with the disease and their loved ones. The disease can cause significant physical and emotional challenges.


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